p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α

Peroxisome Proliferator-Activated Receptor

Peroxisome proliferator - activated receptor

The peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. The discovery of PPARγ as a target of multimodal insulin sensitizers has attracted remarkable scientific interest and had a great impact on the pharmaceutical industry. Thi...

Peroxisome Proliferator-Activated Receptor

Regulation of peroxisome proliferator-activated receptor-γ by angiotensin II via transforming growth factor-β1-activated p38 mitogen-activated protein kinase in aortic smooth muscle cells.

OBJECTIVE Peroxisome proliferator-activated receptor-γ (PPARγ) ligands attenuate angiotensin II (Ang II)-induced atherosclerosis through interactions with vascular smooth muscle cell (VSMC)-specific PPARγ in hypercholesterolemic mice. Therefore, the purpose of this study was to determine the mechanism of Ang II-mediated intracellular regulation of PPARγ in VSMCs. METHODS AND RESULTS Incubatio...

Cell Biology/Signaling Regulation of Peroxisome Proliferator–Activated Receptor- by Angiotensin II Via Transforming Growth Factor- 1–Activated p38 Mitogen-Activated Protein Kinase in Aortic Smooth Muscle Cells

Received on: February 7, 2009; final version accepted on: November 5, 2011. From the Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY (V.S., E.B.H., D.B., A.D.); Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Queensland, Australia (J.G.). Correspondence to Venkateswaran Subramanian, Saha Cardiovascular Research Center, BBSRB, Rm B249, Uni...